Hyperpolarization of Deuterated Metabolites via Remote Cross-Polarization and Dissolution Dynamic Nuclear Polarization

In deuterated molecules such as [1-C-13]pyruvate-d(3), the nuclear spin polarization of C-13 nuclei can be enhanced by combining Hartmann-Hahn cross-polarization (CP) at low temperatures (1.2 K) with dissolution dynamic nuclear polarization (D-DNP). The polarization is transferred from remote solvent protons to the C-13 spins of interest. This allows one not only to slightly reduce build-up times but also to increase polarization levels and extend the lifetimes T-1(C-13) of the enhanced C-13 polarization during and after transfer from the polarizer to the NMR or MRI system. This extends time scales over which metabolic processes and chemical reactions can be monitored.


Published in:
Journal Of Physical Chemistry B, 118, 5, 1411-1415
Year:
2014
Publisher:
Washington, American Chemical Society
ISSN:
1520-6106
Laboratories:


Note: The status of this file is: EPFL only


 Record created 2014-04-02, last modified 2018-03-17

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