000197893 001__ 197893
000197893 005__ 20181203023448.0
000197893 0247_ $$2doi$$a10.1111/pcmr.12236
000197893 022__ $$a1755-148X
000197893 02470 $$2ISI$$a000337619700011
000197893 037__ $$aARTICLE
000197893 245__ $$aNotch signaling in the pigmented epithelium of the anterior eye segment promotes ciliary body development at the expense of iris formation
000197893 260__ $$aHoboken$$bWiley-Blackwell$$c2014
000197893 269__ $$a2014
000197893 300__ $$a11
000197893 336__ $$aJournal Articles
000197893 520__ $$aThe ciliary body and iris are pigmented epithelial structures in the anterior eye segment that function to maintain correct intra-ocular pressure and regulate exposure of the internal eye structures to light, respectively. The cellular and molecular factors that mediate the development of the ciliary body and iris from the ocular pigmented epithelium remain to be fully elucidated. Here, we have investigated the role of Notch signaling during the development of the anterior pigmented epithelium by using genetic loss- and gain-of-function approaches. Loss of canonical Notch signaling results in normal iris development but absence of the ciliary body. This causes progressive hypotony and over time leads to phthisis bulbi, a condition characterized by shrinkage of the eye and loss of structure/function. Conversely, Notch gain-of-function results in aniridia and profound ciliary body hyperplasia, which causes ocular hypertension and glaucoma-like disease. Collectively, these data indicate that Notch signaling promotes ciliary body development at the expense of iris formation and reveals novel animal models of human ocular pathologies.
000197893 6531_ $$aNotch
000197893 6531_ $$aciliary body
000197893 6531_ $$aocular hypertension
000197893 6531_ $$aphthisis bulbi
000197893 6531_ $$aglaucoma
000197893 6531_ $$apigmented epithelium
000197893 6531_ $$airis
000197893 700__ $$0242790$$aSarode, Bhushan$$g182801
000197893 700__ $$aNowell, Craig S.
000197893 700__ $$aIhm, JongEun
000197893 700__ $$aKostic, Corinne
000197893 700__ $$aArsenijevic, Yvan
000197893 700__ $$aMoulin, Alexandre P.
000197893 700__ $$aSchorderet, Daniel F.
000197893 700__ $$0240256$$aBeermann, Friedrich$$g169239
000197893 700__ $$0240231$$aRadtke, Freddy$$g172749
000197893 773__ $$j27$$k4$$q580-9$$tPigment cell & melanoma research
000197893 909C0 $$0252092$$pGR-BEERMANN$$xU11779
000197893 909C0 $$0252086$$pUPRAD$$xU11429
000197893 909CO $$ooai:infoscience.tind.io:197893$$pSV$$particle
000197893 917Z8 $$x169239
000197893 917Z8 $$x169239
000197893 937__ $$aEPFL-ARTICLE-197893
000197893 973__ $$aEPFL$$rNON-REVIEWED$$sPUBLISHED
000197893 980__ $$aARTICLE