Method of enhancing proliferation and/or hematopoietic differentiation of stem cells

The present invention provides methods for inducing differentiation of a stem cell, such as an embryonic stem cell, into a hematopoietic stem cell, by expressing a cdx gene and/or a hox gene. The method is useful for generating expanded populations of hematopoietic stem cells (HSCs) and thus mature blood cell lineages. This is desirable where a mammal has suffered a decrease in hematopoietic or mature blood cells as a consequence of disease, radiation or chemotherapy


    Also published as: WO2007002167 (A9); WO2007002167 (A3); WO2007002167 (A8); US2010209396 (A1)


    Record created on 2014-03-25, modified on 2017-05-12


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