Biomechanical Induction of Hematopoiesis

The present invention provides methods and compositions for increasing the hematopoietic potential of a population of hematopoietic progenitor cells, vascular cells, and or hemogenic endothelium, by exposing the cells to at least one external biomechanical stimulus. More specifically, the application of shear stress to hematopoietic progenitor cells or endothelial cells stimulates hematopoiesis, with or without concurrent application of other extrinsic modulators of hematopoiesis


Year:
2010
Note:
Also published as: WO2010121122 (A2); WO2010121122 (A3)
Patent number(s):
Laboratories:




 Record created 2014-03-25, last modified 2018-01-28


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