000197064 001__ 197064
000197064 005__ 20181203023433.0
000197064 022__ $$a0014-4835
000197064 0247_ $$2doi$$a10.1016/j.exer.2013.11.005
000197064 037__ $$aARTICLE
000197064 245__ $$aPupil responses derived from outer and inner retinal photo reception are normal in patients with hereditary optic neuropathy
000197064 269__ $$a2014
000197064 260__ $$bAcademic Press Ltd- Elsevier Science Ltd$$c2014$$aLondon
000197064 300__ $$a6
000197064 336__ $$aJournal Articles
000197064 520__ $$aWe compared the pupil responses originating from outer versus inner retinal photoreception between patients with isolated hereditary optic neuropathy (HON, n = 8) and healthy controls (n = 8). Three different testing protocols were used. For the first two protocols, a response function of the maximal pupil contraction versus stimulus light intensity was generated and the intensity at which half of the maximal pupil contraction, the half-max intensity, was determined. For the third protocol, the pupil size after light offset, the re-dilation rate and re-dilation amplitude were calculated to assess the post-light stimulus response. Patients with HON had bilateral, symmetric optic atrophy and significant reduction of visual acuity and visual field compared to controls. There were no significant mean differences in the response curve and pupil response parameters that reflect mainly rod, cone or melanopsin activity between patients and controls. In patients, there was a significant correlation between the half-max intensity of the red light sequence and visual field loss. In conclusion, pupil responses derived from outer or inner retinal photoreception in HON patients having mild-to moderate visual dysfunction are not quantitatively different from age-matched controls. However, an association between the degree of visual field loss and the half-max intensity of the cone response suggests that more advanced stages of disease may lead to impaired pupil light reflexes.
000197064 6531_ $$apupil
000197064 6531_ $$apupil light reflex
000197064 6531_ $$ahereditary optic neuropathy
000197064 6531_ $$amelanopsin
000197064 6531_ $$aintrinsically photosensitive retinal ganglion cells
000197064 6531_ $$amelanopsin
000197064 6531_ $$apupil
000197064 6531_ $$apupil light reflex
000197064 6531_ $$acells
000197064 700__ $$0242613$$g188000$$aMünch, Mirjam
000197064 700__ $$uUniv Lausanne, Dept Ophthalmol, Fdn Asile Aveugles, Hop Ophtalm Jules Gonin, CH-1004 Lausanne, Switzerland$$aKawasaki, Aki
000197064 700__ $$uUniv Lausanne, Dept Ophthalmol, Fdn Asile Aveugles, Hop Ophtalm Jules Gonin, CH-1004 Lausanne, Switzerland$$aCollomb, Sylvie
000197064 700__ $$aLeon, Lorette$$uUniv Lausanne, Dept Ophthalmol, Fdn Asile Aveugles, Hop Ophtalm Jules Gonin, CH-1004 Lausanne, Switzerland
000197064 773__ $$j120$$tExperimental Eye Research$$q161-166
000197064 909C0 $$xU10262$$0252072$$pLESO-PB
000197064 909CO $$particle$$pENAC$$ooai:infoscience.tind.io:197064
000197064 917Z8 $$x106442
000197064 917Z8 $$x106442
000197064 937__ $$aEPFL-ARTICLE-197064
000197064 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000197064 980__ $$aARTICLE