000197002 001__ 197002
000197002 005__ 20190316235843.0
000197002 0247_ $$2doi$$a10.1016/j.jpsychires.2014.02.015
000197002 02470 $$2ISI$$a000335104200001
000197002 037__ $$aARTICLE
000197002 245__ $$aCRHR1 links peripuberty stress with deficits in social and stress-coping behaviors
000197002 269__ $$a2014
000197002 260__ $$bPergamon-Elsevier Science Ltd$$c2014$$aOxford
000197002 300__ $$a7
000197002 336__ $$aJournal Articles
000197002 520__ $$aStressful life events during childhood and adolescence are important risk factors for the development of psychopathologies later in life. The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between early life adversity and adult anxiety and depression, with rodent studies identifying the very early postnatal period as highly susceptible to this programming. Here, we investigated whether stress exposure during the peripubertal period - comprising juvenility and puberty - is effective in inducing long-lasting changes in the expression of CRHR1 and CRHR2 in the hippocampus and amygdala, and whether treating animals with a CRHR1 antagonist following stress exposure could reverse behavioral alterations induced by peripuberty stress. We show that peripuberty stress leads to enhanced expression of the Crhr1, but not Crhr2, gene in the hippocampal CA1 and the central nucleus of the amygdala, in association with social deficits in the social exploration test and increased stress-coping behaviors in the forced swim test. Treatment with the CRHR1 antagonist NBI30775 (10 mg/kg) daily for 1 week (from P43 to P49), immediately following peripuberty stress exposure, prevented the occurrence of those psychopathological behaviors at adulthood. These findings highlight peripuberty as a period of plasticity for the enduring modulation of the CRHR1 system and support a growing body of data implicating the CRHR1 system in the programming effects of early life stress on eventual psychopathology. They also support recent evidence indicating that temporarily tackling CRHR1 during development might represent a therapeutic opportunity to correct behavioral trajectories linking early stress to adult psychopathology.
000197002 6531_ $$aPeripuberty stress
000197002 6531_ $$aCorticotropin releasing hormone
000197002 6531_ $$aNBI30775
000197002 6531_ $$aSocial behavior
000197002 6531_ $$aAnxiety-like behavior
000197002 6531_ $$aStress-coping behavior
000197002 700__ $$0243023$$g190656$$aVeenit, Vandana
000197002 700__ $$0245992$$g220575$$aRiccio, Orbicia
000197002 700__ $$0243016$$g160090$$aSandi, Carmen
000197002 773__ $$j53$$tJ Psychiatr Res$$q1-7
000197002 8564_ $$uhttps://infoscience.epfl.ch/record/197002/files/Veenit_CRH1%20links%20peribuberty%20stress.pdf$$zn/a$$s540913$$yn/a
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000197002 937__ $$aEPFL-ARTICLE-197002
000197002 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000197002 980__ $$aARTICLE