000196574 001__ 196574
000196574 005__ 20190604054714.0
000196574 0247_ $$2doi$$a10.1038/pr.2013.242
000196574 022__ $$a1530-0447
000196574 02470 $$2ISI$$a000332433500007
000196574 037__ $$aARTICLE
000196574 245__ $$aDefinition and quantification of acute inflammatory white matter injury in the immature brain by MRI/MRS at high magnetic field
000196574 260__ $$bNature Publishing Group$$c2014$$aNew York
000196574 269__ $$a2014
000196574 300__ $$a9
000196574 336__ $$aJournal Articles
000196574 520__ $$aBackground: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementation with bLf on IUGR-induced sequelae, including inadequate growth and altered cerebral development, remains unknown. Methods: IUGR was induced through maternal dexamethasone infusion (100 μg/kg during last gestational week) in rats. Maternal supplementation with bLf (0.85% in food pellet) was provided during both gestation and lactation. Pup growth was monitored, and Pup brain metabolism and gene expression were studied using in vivo 1H NMR spectroscopy, quantitative PCR, and microarray in the hippocampus at postnatal day (PND)7. Results: Maternal bLf supplementation did not change gestational weight but increased the birth body weight of control pups (4%) with no effect on the IUGR pups. Maternal bLf supplementation allowed IUGR pups to recover a normalized weight at PND21 (weaning) improving catch-up growth. Significantly altered levels of brain metabolites (γ-aminobutyric acid, glutamate, N-acetylaspartate, and N-acetylaspartylglutamate) and transcripts (brain-derived neurotrophic factor (BDNF), divalent metal transporter 1 (DMT-1), and glutamate receptors) in IUGR pups were normalized with maternal bLf supplementation. Conclusion: Our data suggest that maternal bLf supplementation is a beneficial nutritional intervention able to revert some of the IUGR-induced sequelae, including brain hippocampal changes.
000196574 6531_ $$aCIBM-AIT
000196574 700__ $$aLodygensky, Gregory A.
000196574 700__ $$0243715$$g129412$$aKunz, Nicolas
000196574 700__ $$aPerroud, Elodie
000196574 700__ $$aSomm, Emmanuel
000196574 700__ $$0243713$$g168843$$aMlynarik, Vladimir
000196574 700__ $$aHüppi, Petra S.
000196574 700__ $$g161735$$0243712$$aGruetter, Rolf
000196574 700__ $$aSizonenko, Stéphane V.
000196574 773__ $$j75$$tPediatric Research$$k3$$q415-423
000196574 909C0 $$xU10984$$0252276$$pLIFMET
000196574 909C0 $$xU12623$$0252477$$pCIBM
000196574 909CO $$pSB$$particle$$ooai:infoscience.tind.io:196574
000196574 917Z8 $$x161735
000196574 917Z8 $$x161735
000196574 937__ $$aEPFL-ARTICLE-196574
000196574 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000196574 980__ $$aARTICLE