000196515 001__ 196515
000196515 005__ 20180913062350.0
000196515 0247_ $$2doi$$a10.1117/12.203366
000196515 037__ $$aCONF
000196515 245__ $$aEvaluation with mTHPC of early squamous cell carcinomas of the cheek pouch mucosa of Golden Syrian hamsters as a model for clinical PDT of early cancers in the upper aerodigestive tract, the esophagus
000196515 260__ $$c1995
000196515 269__ $$a1995
000196515 336__ $$aConference Papers
000196515 520__ $$aGolden Syrian hamsters are evaluated as an animal model for light induced fluorescence (LIF) photodetection and phototherapy of early squamous cell carcinomas of the upper aerodigestive tract, the esophagus, and the traecheo-bronchial tree. Carcinomas of this type are induced on the hamster cheek pouch mucosa by the application of the carcinogen 7,12-DMBA. For phototherapeutic experiments on the animals we utilized meso-(tetrahydoxyphenyl) chlorin (mTHPC). This drug is currently in phase I and II clinical trials for ENT patients presenting superficial `early' squamous cell carcinomas. By means of LIF we measured in vivo the kinetics of the uptake and removal of mTHPC in the normal and tumoral cheek mucosa and in the skin. The photodynamic therapy (PDT) reaction of the tissue after excitation of the photosensitizer with laser light at 652 nm was studied. Both pharmacokinetics and PDT efficacy are compared between animal model and clinical results with special emphasis on selectivity between normal and tumoral mucosa. These first experiments show that this tumor model in the hamster cheek pouch seems to be suitable for testing new photosensitizers preceding their clinical application as well as for optimization of the multiple parameters of clinical PDT.
000196515 700__ $$aGlanzmann, Th.
000196515 700__ $$aTheumann, Jean-Francois
000196515 700__ $$aForrer, Martin
000196515 700__ $$aBraichotte, Daniel
000196515 700__ $$0241203$$aWagnieres, Georges$$g106697
000196515 700__ $$0240886$$aBergh, Hubert$$g106613
000196515 700__ $$aAndrejevic, Snezana
000196515 700__ $$aSavary, Jean-Francois
000196515 700__ $$aMonnier, Philippe
000196515 773__ $$j2371$$q51-58$$tProceedings of SPIE - The International Society for Optical Engineering
000196515 909C0 $$0252376$$pLPAS
000196515 909CO $$ooai:infoscience.tind.io:196515$$pconf
000196515 917Z8 $$x171848
000196515 937__ $$aEPFL-CONF-196515
000196515 973__ $$aEPFL$$rNON-REVIEWED$$sPUBLISHED
000196515 980__ $$aCONF