000196505 001__ 196505
000196505 005__ 20190812205739.0
000196505 0247_ $$2doi$$a10.1117/12.240028
000196505 037__ $$aCONF
000196505 245__ $$aUsefulness of fluorescence photodetection of neoplastic urothelial foci in bladder cancer following intravesical instillation of delta-aminolevulinic acid (5-ALA)
000196505 260__ $$c1996
000196505 269__ $$a1996
000196505 336__ $$aConference Papers
000196505 520__ $$aAn excellent knowledge of histopathological risk factors of superficial bladder transitional cell carcinoma is mandatory to establish the prognosis of the disease. Presence or absence of carcinoma in situ (CIS) in superficial bladder cancer is one of the most powerful risk indicators. This study examines the usefulness of fluorescence photodetection of neoplastic urothelial foci in bladder cancer following intravesical instillation of delta-aminolevulinic acid (5-ALA). Following bladder instillation of an aqueous solution of 5-ALA in 43 cases, a Krypton ion laser and a Xenon arc-lamp were successively used as excitation source of the PPIX fluorescence. Tissular samples were respectively taken during bladder wall photodetection, either by the means of a video camera, or under direct endoscopic observation. A good correlation was observed between the fluorescence findings and the histopathological diagnosis. On a total of 298 biopsies, 49/110 carcinomatous lesions were detected by the fluorescence, whose more than 36% were CIS. PPIX induced fluorescence with topical bladder instillation of 5-ALA is an efficient and useful method of mapping the mucosa in bladder carcinoma. Moreover, in case of a multifocal disease, this method seems very helpful in finding and treating any residual malignant spots at the end of a transurethral bladder resection.
000196505 700__ $$aJichlinski, Patrice M. D.
000196505 700__ $$aForrer, Martin
000196505 700__ $$aMizeret, Jerome C.
000196505 700__ $$aBraichotte, Daniel
000196505 700__ $$0241203$$g106697$$aWagnieres, Georges
000196505 700__ $$aZimmer, Georges
000196505 700__ $$aGuillou, Louis
000196505 700__ $$aSchmidlin, Franz
000196505 700__ $$aGraber, Peter
000196505 700__ $$g106613$$aVan den Bergh, Hubert$$0240886
000196505 700__ $$aLeisinger, Hans-Jurg
000196505 773__ $$j2671$$tProceedings of SPIE - The International Society for Optical Engineering$$q340-347
000196505 909C0 $$pLPAS$$0252376$$xU10271
000196505 909CO $$pconf$$ooai:infoscience.tind.io:196505
000196505 917Z8 $$x171848
000196505 937__ $$aEPFL-CONF-196505
000196505 973__ $$rNON-REVIEWED$$sPUBLISHED$$aEPFL
000196505 980__ $$aCONF