000196266 001__ 196266
000196266 005__ 20181203023420.0
000196266 0247_ $$2doi$$a10.1002/adfm.201301628
000196266 022__ $$a1616-301X
000196266 02470 $$2ISI$$a000331084300002
000196266 037__ $$aARTICLE
000196266 245__ $$aOn-Chip Fabrication of Paclitaxel-Loaded Chitosan Nanoparticles for Cancer Therapeutics
000196266 260__ $$bWiley-Blackwell$$c2014$$aWeinheim
000196266 269__ $$a2014
000196266 300__ $$a10
000196266 336__ $$aJournal Articles
000196266 520__ $$aThe use of solvent-free microfluidics to fine-tune the physical and chemical properties of chitosan nanoparticles for drug delivery is demonstrated. Nanoparticle self-assembly is driven by pH changes in a water environment, which increases biocompatibility by avoiding organic solvent contamination common with traditional techniques. Controlling the time of mixing (2.5–75 ms) during nanoparticle self-assembly enables us to adjust nanoparticle size and surface potential in order to maximize cellular uptake, which in turn dramatically increases drug effectiveness. The compact nanostructure of these nanoparticles preserves drug potency better than previous nanoparticles, and is more stable during long-term circulation at physiological pH. However, when the nanoparticles encounter a tumor cell and the associated drop in pH, the drug contents are released. Moreover, the loading efficiency of hydrophobic drugs into the nanoparticles increases significantly from previous work to over 95%. The microfluidic techniques used here have applications not just for drug-carrying nanoparticle fabrication, but also for the better control of virtually any self-assembly process.
000196266 6531_ $$amicrofluidics
000196266 6531_ $$ananoparticles
000196266 6531_ $$adrug delivery
000196266 6531_ $$acancer therapeutics
000196266 6531_ $$alab on chip devices
000196266 700__ $$aMajedi, Fatemeh Sadat
000196266 700__ $$aHasani-Sadrabadi, Mohammad Mahdi
000196266 700__ $$0246178$$g221719$$aVandersarl, Jules John
000196266 700__ $$aMokarram, Nassir
000196266 700__ $$aHojjati-Emami, Shahirar
000196266 700__ $$aDashtimoghadam, Erfan
000196266 700__ $$aBonakdar, Shahin
000196266 700__ $$aShokrgozar, Mohammad Ali
000196266 700__ $$0240202$$g113143$$aBertsch, Arnaud
000196266 700__ $$aRenaud, Philippe$$g107144$$0240219
000196266 773__ $$j24$$tAdvanced Functional Materials$$k4$$q432-441
000196266 909C0 $$xU10324$$0252064$$pLMIS4
000196266 909CO $$pSTI$$particle$$ooai:infoscience.tind.io:196266
000196266 917Z8 $$x113143
000196266 937__ $$aEPFL-ARTICLE-196266
000196266 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000196266 980__ $$aARTICLE