000195417 001__ 195417
000195417 005__ 20180913062315.0
000195417 0247_ $$2doi$$a10.1371/journal.pone.0081206
000195417 022__ $$a1932-6203
000195417 02470 $$2ISI$$a000327949300081
000195417 037__ $$aARTICLE
000195417 245__ $$aPerception of Social Cues of Danger in Autism Spectrum Disorders
000195417 260__ $$aSan Francisco$$bPublic Library Science$$c2013
000195417 269__ $$a2013
000195417 300__ $$a9
000195417 336__ $$aJournal Articles
000195417 520__ $$aIntuitive grasping of the meaning of subtle social cues is particularly affected in autism spectrum disorders (ASD). Despite their relevance in social communication, the effect of averted gaze in fearful faces in conveying a signal of environmental threat has not been investigated using real face stimuli in adults with ASD. Here, using functional MRI, we show that briefly presented fearful faces with averted gaze, previously shown to be a strong communicative signal of environmental danger, produce different patterns of brain activation than fearful faces with direct gaze in a group of 26 normally intelligent adults with ASD compared with 26 matched controls. While implicit cue of threat produces brain activation in attention, emotion processing and mental state attribution networks in controls, this effect is absent in individuals with ASD. Instead, individuals with ASD show activation in the subcortical face-processing system in response to direct eye contact. An effect of differences in looking behavior was excluded in a separate eye tracking experiment. Our data suggest that individuals with ASD are more sensitive to direct eye contact than to social signals of danger conveyed by averted fearful gaze.
000195417 700__ $$aZuercher, Nicole R.$$uEcole Polytech Fed Lausanne, Brain Mind Inst, CH-1015 Lausanne, Switzerland
000195417 700__ $$aRogier, Ophelie$$uEcole Polytech Fed Lausanne, Brain Mind Inst, CH-1015 Lausanne, Switzerland
000195417 700__ $$aBoshyan, Jasmine$$uHarvard Univ, Sch Med, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
000195417 700__ $$0244887$$aHippolyte, Loyse$$g199487$$uEcole Polytech Fed Lausanne, Brain Mind Inst, CH-1015 Lausanne, Switzerland
000195417 700__ $$aRusso, Britt$$uEcole Polytech Fed Lausanne, Brain Mind Inst, CH-1015 Lausanne, Switzerland
000195417 700__ $$aGillberg, Nanna$$uUniv Gothenburg, Gillberg Centrum, Gothenburg, Sweden
000195417 700__ $$aHelles, Adam$$uUniv Gothenburg, Gillberg Centrum, Gothenburg, Sweden
000195417 700__ $$0245469$$aRuest, Torsten$$g214607$$uEcole Polytech Fed Lausanne, Brain Mind Inst, CH-1015 Lausanne, Switzerland
000195417 700__ $$aLemonnier, Eric
000195417 700__ $$aGillberg, Christopher$$uUniv Gothenburg, Gillberg Centrum, Gothenburg, Sweden
000195417 700__ $$0244725$$aHadjikhani, Nouchine$$g173075$$uEcole Polytech Fed Lausanne, Brain Mind Inst, CH-1015 Lausanne, Switzerland
000195417 773__ $$j8$$k12$$tPlos One
000195417 909C0 $$0252336$$pGRHAD$$xU11526
000195417 909CO $$ooai:infoscience.tind.io:195417$$particle
000195417 937__ $$aEPFL-ARTICLE-195417
000195417 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000195417 980__ $$aARTICLE