000190582 001__ 190582
000190582 005__ 20181203023328.0
000190582 022__ $$a0142-9612
000190582 02470 $$2ISI$$a000331018700011
000190582 0247_ $$2doi$$a10.1016/j.biomaterials.2013.11.048
000190582 037__ $$aARTICLE
000190582 245__ $$aThe role of energy dissipation of polymeric scaffolds in the mechanobiological modulation of chondrogenic expression
000190582 269__ $$a2014
000190582 260__ $$c2014
000190582 336__ $$aJournal Articles
000190582 520__ $$aMechanical stimulation has been proposed to induce chondrogenesis in cell-seeded scaffold. However, the effects of mechanical stimuli on engineered cartilage may vary substantially between different scaffolds. This advocates for the need to identify an overarching mechanobiological variable. We hypothesize that energy dissipation of scaffolds subjected to dynamic loading may be used as a mechanobiology variable. The energy dissipation would furnish a general criterion to adjust the mechanical stimulation favoring chondrogenesis in scaffold. Epiphyseal chondro-progenitor cells were then subject to unconfined compression two hours per day during four days in different scaffolds, which differ only by the level of dissipation they generated while keeping the same loading conditions. Scaffolds with higher dissipation levels upregulated the mRNA of chondrogenic markers. In contrast lower dissipation of scaffolds was associated with downregulation of chondrogenic markers. These results showed that energy dissipation could be considered as a mechanobiology variable in cartilage. This study also indicated that scaffold with energy dissipation level close to the one of cartilage favors chondrogenic expression when dynamical loading is present.
000190582 6531_ $$acartilage
000190582 6531_ $$adissipation
000190582 6531_ $$achondrogenic expression
000190582 6531_ $$amechanobiology
000190582 6531_ $$ascaffold
000190582 6531_ $$adynamic compression
000190582 700__ $$0244246$$aAbdel-Sayed, Philippe$$g166505
000190582 700__ $$0244247$$aDarwiche, Salim Elias$$g191919
000190582 700__ $$0244461$$aKettenberger, Ulrike$$g204848
000190582 700__ $$0240508$$aPioletti, Dominique$$g103117
000190582 773__ $$j35$$k6$$q1890-1897$$tBiomaterials
000190582 8564_ $$s2019450$$uhttps://infoscience.epfl.ch/record/190582/files/Biomaterial%28Philippe%29_1.pdf
000190582 909C0 $$0252108$$pLBO$$xU10299
000190582 909CO $$ooai:infoscience.tind.io:190582$$pSTI$$particle
000190582 917Z8 $$x103117
000190582 917Z8 $$x103117
000190582 917Z8 $$x103117
000190582 917Z8 $$x103117
000190582 937__ $$aEPFL-ARTICLE-190582
000190582 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000190582 980__ $$aARTICLE