Palladium-Catalyzed Through-Space C(sp3)-H and C(sp2)-H Bond Activation by 1,4-Palladium Migration: Efficient Synthesis of [3,4]- Fused Oxindoles

Palladium two step: Linear anilides were converted into the title compounds in good to excellent yields through a palladium-catalyzed domino carbopalladation/1,4-palladium shift sequence. The C(sp3)-H activation involves a seven-membered palladacycle, and is chemoselective in the presence of competitive C(sp2)H bonds. DMA=N,N-dimethylacetamide, OPiv=pivalate.


Published in:
Angewandte Chemie International Edition, 52, 47, 12385-12389
Year:
2013
Publisher:
Weinheim, Wiley-Blackwell
ISSN:
1433-7851
Keywords:
Laboratories:




 Record created 2013-11-13, last modified 2018-03-17


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