Total Synthesis and Biological Evaluation of Jerantinine E

The first total synthesis of the alkaloid natural product jerantinine E is based on a selective cyclization of an aminocyclopropane. Preliminary investigations show that it inhibits the polymerization of tubulin, displaying significant cytotoxicity and antimigratory activity against both breast and lung cancer cell lines.


Published in:
Angewandte Chemie -International Edition in English-, 52, 50, 13373–13376
Year:
2013
Publisher:
Wiley-Blackwell
ISSN:
1433-7851
Keywords:
Laboratories:




 Record created 2013-10-22, last modified 2018-12-03

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