Heteroannulation of arynes with N-aryl-α-aminoketones for the synthesis of unsymmetrical N-aryl-2,3-disubstituted indoles: an aryne twist of Bischler–Möhlau indole synthesis

Reaction of 2-(trimethylsilyl)aryl triflates 1 with N-aryl-a-amino ketones 2 afforded N-aryl-2,3-disubstituted indoles in good to excellent yields with complete control of the substitution patterns. This methodology allowed for the first time a one-step synthesis of unsymmetrical 2,3-dialkyl substituted indoles in a regiospecific manner.


Published in:
Chemical Communications, 49, 87, 10284
Year:
2013
Publisher:
Cambridge, Royal Soc Chemistry
ISSN:
1364-548X
Laboratories:




 Record created 2013-10-15, last modified 2018-03-17


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