Temporal whitening by power-law adaptation in neocortical neurons

Spike-frequency adaptation (SFA) is widespread in the CNS, but its function remains unclear. In neocortical pyramidal neurons, adaptation manifests itself by an increase in the firing threshold and by adaptation currents triggered after each spike. Combining electrophysiological recordings in mice with modeling, we found that these adaptation processes lasted for more than 20 s and decayed over multiple timescales according to a power law. The power-law decay associated with adaptation mirrored and canceled the temporal correlations of input current received in vivo at the somata of layer 2/3 somatosensory pyramidal neurons. These findings suggest that, in the cortex, SFA causes temporal decorrelation of output spikes (temporal whitening), an energy-efficient coding procedure that, at high signal-to-noise ratio, improves the information transfer.


Published in:
Nature Neuroscience, 16, 7, 942-966
Year:
2013
Publisher:
New York, Nature Publishing Group
ISSN:
1097-6256
Laboratories:




 Record created 2013-10-01, last modified 2018-09-13

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