000189211 001__ 189211
000189211 005__ 20180913062049.0
000189211 0247_ $$2doi$$a10.1016/j.jbiomech.2013.02.011
000189211 022__ $$a0021-9290
000189211 02470 $$2ISI$$a000318583800011
000189211 037__ $$aARTICLE
000189211 245__ $$aTheoretical bounds for the influence of tissue-level ductility on the apparent-level strength of human trabecular bone
000189211 260__ $$aOxford$$bElsevier Sci Ltd$$c2013
000189211 269__ $$a2013
000189211 300__ $$a7
000189211 336__ $$aJournal Articles
000189211 520__ $$aThe role of tissue-level post-yield behavior on the apparent-level strength of trabecular bone is a potentially important aspect of bone quality. To gain insight into this issue, we compared the apparent-level strength of trabecular bone for the hypothetical cases of fully brittle versus fully ductile failure behavior of the trabecular tissue. Twenty human cadaver trabecular bone specimens (5 mm cube; BV/TV=6-36%) were scanned with micro-CT to create 3D finite element models (22-micron element size). For each model, apparent-level strength was computed assuming either fully brittle (fracture with no tissue ductility) or fully ductile (yield with no tissue fracture) tissue-level behaviors. We found that the apparent-level ultimate strength for the brittle behavior was only about half the value of the apparent-level 0.2%-offset yield strength for the ductile behavior, and the ratio of these brittle to ductile strengths was almost constant (mean +/- SD=0.56 +/- 0.02; n=20; R-2=0.99 between the two measures). As a result of this small variation, although the ratio of brittle to ductile strengths was positively correlated with the bone volume fraction (R-2=0.44, p=0.01) and structure model index (SMI, R-2=0.58, p < 0.01), these effects were small. Mechanistically, the fully ductile behavior resulted in a much higher apparent-level strength because in this case about 16-fold more tissue was required to fail than for the fully brittle behavior; also, there was more tensile- than compressive-mode of failure at the tissue level for the fully brittle behavior. We conclude that, in theory, the apparent-level strength behavior of human trabecular bone can vary appreciably depending on whether the tissue fails in a fully ductile versus fully brittle manner, and this effect is largely constant despite appreciable variations in bone volume fraction and microarchitecture. (C) 2013 Elsevier Ltd. All rights reserved.
000189211 6531_ $$aFinite element analysis
000189211 6531_ $$aBone quality
000189211 6531_ $$aBrittle
000189211 6531_ $$aDuctile
000189211 6531_ $$aMicroarchitecture
000189211 700__ $$aNawathe, Shashank$$uUniv Calif Berkeley, Dept Mech Engn, Orthopaed Biomech Lab, Berkeley, CA 94720 USA
000189211 700__ $$aJuillard, Frederic$$uUniv Calif Berkeley, Dept Mech Engn, Orthopaed Biomech Lab, Berkeley, CA 94720 USA
000189211 700__ $$aKeaveny, Tony M.$$uUniv Calif Berkeley, Dept Mech Engn, Orthopaed Biomech Lab, Berkeley, CA 94720 USA
000189211 773__ $$j46$$k7$$q1293-1299$$tJournal Of Biomechanics
000189211 909C0 $$0252442$$pIPSB$$xU11993
000189211 909CO $$ooai:infoscience.tind.io:189211$$particle
000189211 937__ $$aEPFL-ARTICLE-189211
000189211 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000189211 980__ $$aARTICLE