One-pot total chemical synthesis of human α-synuclein

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.


Published in:
Chemical communications (Cambridge, England), 49, 81, 9254-6
Year:
2013
Publisher:
Cambridge, Royal Soc Chemistry
ISSN:
1364-548X
Laboratories:




 Record created 2013-09-24, last modified 2018-03-17

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