Synthetic Study towards Strictamine: The Oxidative Coupling Approach
Ren, Weiwu; Tappin, Nicholas; Wang, Qian; Zhu, Jieping
2013

Abstract

A synthetic approach featuring a key intramolecular oxidative coupling of a dianion for the formation of the C7–C16 bond was exploited aiming at the synthesis of strictamine. Treatment of substituted tetrahydrocarboline with LHMDS at –78 °C followed by iodine at room temperature afforded a tetracyclic compound, a substructure of eburnane-type alkaloid, via the formation of the Na–C16 bond.

Details

Title Synthetic Study towards Strictamine: The Oxidative Coupling Approach
Author(s) Ren, Weiwu ; Tappin, Nicholas ; Wang, Qian ; Zhu, Jieping
Published in Synlett
Pagination 4
Volume 24
Pages 1941-1944
Date 2013
Publisher Stuttgart, Georg Thieme Verlag Kg
ISSN 1437-2096
Keywords
DOI https://doi.org/10.1055/s-0033-1339472
Other identifier(s) View record in Web of Science
Laboratories LSPN
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Work produced at EPFL
Journal Articles
Published
Record creation date 2013-09-14

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