Synthetic Study towards Strictamine: The Oxidative Coupling Approach

A synthetic approach featuring a key intramolecular oxidative coupling of a dianion for the formation of the C7–C16 bond was exploited aiming at the synthesis of strictamine. Treatment of substituted tetrahydrocarboline with LHMDS at –78 °C followed by iodine at room temperature afforded a tetracyclic compound, a substructure of eburnane-type alkaloid, via the formation of the Na–C16 bond.


Published in:
Synlett, 24, 1941-1944
Year:
2013
Publisher:
Stuttgart, Georg Thieme Verlag Kg
ISSN:
1437-2096
Keywords:
Laboratories:




 Record created 2013-09-14, last modified 2018-03-17


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