Macrophage regulation of tumor responses to anticancer therapies

Tumor-associated macrophages (TAMs) promote key processes in tumor progression, like angiogenesis, immunosuppression, invasion, and metastasis. Increasing studies have also shown that TAMs can either enhance or antagonize the antitumor efficacy of cytotoxic chemotherapy, cancer-cell targeting antibodies, and immunotherapeutic agents--depending on the type of treatment and tumor model. TAMs also drive reparative mechanisms in tumors after radiotherapy or treatment with vascular-targeting agents. Here, we discuss the biological significance and clinical implications of these findings, with an emphasis on novel approaches that effectively target TAMs to increase the efficacy of such therapies.


Published in:
Cancer cell, 23, 3, 277-86
Year:
2013
ISSN:
1878-3686
Laboratories:


Note: The status of this file is: Involved Laboratories Only


 Record created 2013-09-05, last modified 2018-03-17

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