With the introduction of higher seismic design forces in the Swiss loading standard of 2003 most unreinforced masonry (URM) buildings failed to satisfy the seismic design check. For this reason, in new construction projects, a number of URM walls are nowadays replaced by reinforced concrete (RC) walls. The lateral bracing system of the resulting structure consists therefore of URM walls and some RC walls which are coupled by RC slabs and masonry spandrels. Within the scope of a FP7-Series project a four-storey RC-URM wall structure is tested on the shake-table at the TREES laboratory of the EUCENTRE in Pavia (Italy). The test is conducted at half-scale and is part of a larger research initiative on mixed RC-URM wall systems initiated at EPFL. The key objective of the test is to gain insights into the dynamic behaviour of RC-URM wall structures and to provide input for the definition of a performance-based design approach of such mixed structural system. This paper presents details on the structural system, the instrumentation and the selected ground motion and discusses preliminary results of the shake-table test.