Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications
Passemard, Solène; Städler, Davide; Ucnova, Lucia; Schneiter, Guillaume Stéphane; Kong, Phally; Bonacina, Luigi; Gerber-Lemaire, Sandrine
2013

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Abstract

A straightforward route is proposed for the multi-gram scale synthesis of heterobifunctional poly(ethylene glycol) (PEG) oligomers containing combination of triethyloxysilane extremity for surface modification of metal oxides and amino or azido active end groups for further functionalization. The suitability of these PEG derivatives to be conjugated to nanomaterials was shown by pegylation of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles (NPs), followed by functionalization with small peptide ligands for biomedical applications.

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Title Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications
Author(s) Passemard, Solène ; Städler, Davide ; Ucnova, Lucia ; Schneiter, Guillaume Stéphane ; Kong, Phally ; Bonacina, Luigi ; Gerber-Lemaire, Sandrine
Published in Bioorganic and Medicinal Chemistry Letters
Pagination 5
Volume 23
Pages 5006-5010
Date 2013
Publisher Oxford, Elsevier
ISSN 0960-894X
Keywords
DOI https://doi.org/10.1016/j.bmcl.2013.06.037
Other identifier(s) View record in Web of Science
Laboratories LSPN
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LSPN - Laboratory of synthesis and natural products
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2013-06-12

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