Ugi Four-Component Reaction of Alcohols: Stoichiometric and Catalytic Oxidation/MCR Sequences

A new, simple, and efficient procedure for the one-pot Ugi four-component reaction of alcohols instead of aldehydes is described. Using a stoichiometric amount of IBX or only 1-2% of sodium 2-iodobenzenesulfonate in the presence of Oxone, a wide range of primary alcohols were oxidized to the aldehyde that were directly engaged in the Ugi four-component reaction to afford alpha-acetamidoamides in good to excellent yields.


Published in:
Organic Letters, 15, 11, 2854-2857
Year:
2013
Publisher:
Washington, Amer Chemical Soc
ISSN:
1523-7052
Laboratories:




 Record created 2013-06-07, last modified 2018-09-13


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