000186573 001__ 186573
000186573 005__ 20190316235632.0
000186573 0247_ $$2doi$$a10.1098/rstb.2012.0367
000186573 022__ $$a1471-2970
000186573 02470 $$2ISI$$a000318614800009
000186573 037__ $$aARTICLE
000186573 245__ $$aChromatin organization and global regulation of Hox gene clusters
000186573 260__ $$aLondon$$bRoyal Soc$$c2013
000186573 269__ $$a2013
000186573 300__ $$a8
000186573 336__ $$aJournal Articles
000186573 520__ $$aDuring development, a properly coordinated expression of Hox genes, within their different genomic clusters is critical for patterning the body plans of many animals with a bilateral symmetry. The fascinating correspondence between the topological organization of Hox clusters and their transcriptional activation in space and time has served as a paradigm for understanding the relationships between genome structure and function. Here, we review some recent observations, which revealed highly dynamic changes in the structure of chromatin at Hox clusters, in parallel with their activation during embryonic development. We discuss the relevance of these findings for our understanding of large-scale gene regulation.
000186573 6531_ $$aembryonic patterning
000186573 6531_ $$acollinearity
000186573 6531_ $$achromatin architecture
000186573 6531_ $$along-range regulation
000186573 6531_ $$anuclear organization
000186573 700__ $$aMontavon, T.
000186573 700__ $$0240276$$aDuboule, D.$$g141236
000186573 773__ $$j368$$k1620$$q20120367-20120367$$tPhilosophical Transactions of the Royal Society B: Biological Sciences
000186573 8564_ $$uhttp://www.ncbi.nlm.nih.gov/pubmed/23650639$$zURL
000186573 909C0 $$0252099$$pUPDUB$$xU11705
000186573 909CO $$ooai:infoscience.tind.io:186573$$pSV$$particle$$qGLOBAL_SET
000186573 917Z8 $$x182482
000186573 937__ $$aEPFL-ARTICLE-186573
000186573 973__ $$aEPFL$$rNON-REVIEWED$$sPUBLISHED
000186573 980__ $$aARTICLE