Synthesis of Functionalized Spiroindolines via Palladium-Catalyzed Methine C-H Arylation
Saget, Tanguy; Perez, David; Cramer, Nicolai
2013

Abstract

The synthesis of cyclopropyl spiroindolines is described using an intramolecular palladium(0)-catalyzed C-H functionalization of a methine C(sp(3))-H bond. This transformation can be coupled with intermolecular Suzuki couplings or direct arylations of heteroaromatics to access functionalized indoline scaffolds in a single step.

Details

Title Synthesis of Functionalized Spiroindolines via Palladium-Catalyzed Methine C-H Arylation
Author(s) Saget, Tanguy ; Perez, David ; Cramer, Nicolai
Published in Organic Letters
Pagination 4
Volume 15
Issue 6
Pages 1354-1357
Date 2013
Publisher Washington, Amer Chemical Soc
ISSN 1523-7060
DOI https://doi.org/10.1021/ol400380y
Other identifier(s) View record in Web of Science
Laboratories LCSA
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCSA - Laboratory of Asymmetric Catalysis and Synthesis
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2013-05-13

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