Metabolite concentration changes during motor activation using functional Magnetic Resonance Spectroscopy (fMRS) at 7T

Functional MR spectroscopy (fMRS) allows to investigate the metabolic response of the brain to a physiological stimulation, by acquiring continuously MR spectra during a functional task, and provides direct insights into brain metabolism. For the studies of dynamic concentration changes using fMRS, a high time evolution is of advantage for the characterization of the very small transient changes (around 0.2μmol/g). Therefore, measurements with the highest sensitivity are desirable. Recent studies at high field (7 Tesla) reported small metabolite concentration changes (around 0.2µmol/g) and in particular a lactate concentration increase varying between 10-23% during visual stimulation. Additionally, it is interesting to investigate metabolite changes during other stimulation. Therefore, the aim of this study was to investigate the metabolite changes during motor activation in the human brain and to compare these changes with those of visual activation.

Published in:
Proceedings of the 21th ISMRM meeting
Presented at:
21st Annual Meeting of the International Society of Magnetir Resonance in Medicine (ISMRM), Salt Lake City, April 20-27, 2013

 Record created 2013-05-07, last modified 2018-03-18

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