Surface Modification of Biomaterials for Conjugation with Human Fetal Osteoblasts

Surface functionalization of hydroxyapatite (HA) and β-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants.


Published in:
Chimia, 67, 213-217
Year:
2013
Publisher:
Bern, Swiss Chemical Soc
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 Record created 2013-05-02, last modified 2018-03-18

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