Pd(II)-catalyzed intramolecular aminopalladation/direct C–H arylation under aerobic conditions: synthesis of pyrrolo[1,2-a]indoles

Heating a DMA/pivalic acid (v/v = 4/1) solution of diversely substituted 6-(phenylamino)hex-2-ynoates in the presence of a catalytic amount of Pd(OAc)2 under oxygen atmosphere afforded pyrrolo[1,2-a]indoles in moderate to good yields. A domino sequence involving intramolecular aminopalladation followed by C-H activation and reductive elimination was proposed to account for the observed bis-cyclization.


Published in:
Tetrahedron, 69, 22, 4415-4420
Year:
2013
Publisher:
Oxford, Elsevier
ISSN:
0040-4020
Keywords:
Laboratories:




 Record created 2013-05-01, last modified 2018-09-13


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