MicroRNA-mediated control of macrophages and its implications for cancer

Deregulation of microRNAs (miRNAs) can drive oncogenesis, tumor progression, and metastasis by acting cell-autonomously in cancer cells. However, solid tumors are also infiltrated by large amounts of non-neoplastic stromal cells, including macrophages, which express several active miRNAs. Tumor-associated macrophages (TAMs) enhance angiogenic, immunosuppressive, invasive, and metastatic programming of neoplastic tissue and reduce host survival. Here, we review the role of miRNAs (including miR-155, miR-146, and miR-511) in the control of macrophage production and activation, and examine whether reprogramming miRNA activity in TAMs and/or their precursors might be effective for controlling tumor progression.


Published in:
Trends in immunology, 34, 7, 350-9
Year:
2013
Publisher:
Oxford, Elsevier Sci Ltd
ISSN:
1471-4981
Keywords:
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Note: The status of this file is: Involved Laboratories Only


 Record created 2013-04-25, last modified 2018-03-17

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