Synthesis, characterisation and in vitro anticancer activity of hexanuclear thiolato-bridged arene ruthenium metallaprisms
Furrer, M. A.; Garci, A.; Denoyelle-Di-Muro, E.; Trouillas, P.; Giannini, F.; Furrer, J.; Clavel, C. M.; Dyson, Paul Joseph; Süss-Fink, G.; Therrien, B.
2013

Abstract

Hexanuclear thiolato-bridged arene ruthenium metalla-prisms of the general formula [(p-cymene)6Ru6(SR)6(tpt)2]6+ (R=CH2Ph, CH2C6H4-p-tBu, CH2CH2Ph; tpt=2,4,6-tris(4-pyridyl)-1,3,5-triazine), obtained from the dinuclear precursors [(p-cymene)2Ru2(SR)2Cl2], AgCF3SO3 and tpt, have been isolated and fully characterised as triflate salts. The metalla-prisms are highly cytotoxic against human ovarian cancer cells, especially towards the cisplatin-resistant cell line A2780cisR (IC50 <0.25M).

Details

Title Synthesis, characterisation and in vitro anticancer activity of hexanuclear thiolato-bridged arene ruthenium metallaprisms
Author(s) Furrer, M. A. ; Garci, A. ; Denoyelle-Di-Muro, E. ; Trouillas, P. ; Giannini, F. ; Furrer, J. ; Clavel, C. M. ; Dyson, Paul Joseph ; Süss-Fink, G. ; Therrien, B.
Published in Chem. Eur. J.
Pagination 6
Volume 19
Pages 3198-3203
Date 2013
Publisher Weinheim, Wiley-V C H Verlag Gmbh
Keywords
DOI https://doi.org/10.1002/chem.201203712
Other identifier(s) View record in Web of Science
Laboratories LCOM
Record Appears in Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2013-03-26

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