Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death
2013
Abstract
Two hybrid compounds comprising an antimetastatic rutheniumarene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.
Details
Title
Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death
Author(s)
Nazarov, A. ; Gardini, D. ; Baquié, M. ; Juillerat-Jeanneret, L. ; Serkova, T. P. ; Shevtsova, E. P. ; Scopelliti, R. ; Dyson, Paul Joseph
Published in
Dalton Transactions
Pagination
4
Volume
42
Pages
2347-2350
Date
2013
Publisher
Cambridge, Royal Society of Chemistry
ISSN
1477-9226
Other identifier(s)
View record in Web of Science
Laboratories
LCOM
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2013-03-26