X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues
Chien, C.-C.; Cheng, C.-C.; Chen, H. H.; Hwu, Y.; Chu, Y. S.; Petibois, C.; Chen, A.; Ching, Y.-T.; Margaritondo, G.
2012

Abstract

We demonstrate that, with appropriate staining, high-resolution X-ray microscopy can image complicated tissue structures-cerebellum and liver-and resolve large or small amounts of Au nanoparticles in these tissues. Specifically, images of tumor tissue reveal high concentrations of accumulated Au nanoparticles. PEG (poly(ethylene glycol)) coating is quite effective in enhancing this accumulation and significantly modifies the mechanism of uptake by reticuloendothelial system (RES) organs.

Details

Title X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues
Author(s) Chien, C.-C. ; Cheng, C.-C. ; Chen, H. H. ; Hwu, Y. ; Chu, Y. S. ; Petibois, C. ; Chen, A. ; Ching, Y.-T. ; Margaritondo, G.
Published in Analytical And Bioanalytical Chemistry
Pagination 10
Volume 404
Issue 5
Pages 1287-1296
Date 2012
Publisher Heidelberg, Springer Heidelberg
ISSN 1618-2642
Keywords
DOI https://doi.org/10.1007/s00216-012-6217-y
Other identifier(s) View record in Web of Science
Laboratories LPRX
Record Appears in Scientific production and competences > SB - School of Basic Sciences > SB Archives > LPRX - X-Ray Physics Laboratory
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2013-02-27