Slawinska et al. questioned the involvement of supraspinal centers in restoring locomotion after multisystem neuroprosthetic training in rats with paralyzing spinal cord injury. Here, we clarify misconceptions and present additional results illustrating the robust influence of brain input on electrochemically enabled spinal circuitries. We reassert that our intervention reestablished supraspinal control over hindlimb locomotion in paralyzed rats.