000183546 001__ 183546
000183546 005__ 20190420183722.0
000183546 0247_ $$2doi$$a10.1093/nar/gks1092
000183546 022__ $$a0305-1048
000183546 02470 $$2ISI$$a000312893300015
000183546 037__ $$aARTICLE
000183546 245__ $$aUCNEbase – a database of ultra-conserved non-coding elements and genomic regulatory blocks
000183546 269__ $$a2013
000183546 260__ $$aOxford$$bOxford University Press$$c2013
000183546 300__ $$a9
000183546 336__ $$aJournal Articles
000183546 520__ $$aUCNEbase (http://ccg.vital-it.ch/UCNEbase) is a free, web-accessible information resource on the evolution and genomic organization of ultra-conserved non-coding elements (UCNEs). It currently covers 4351 such elements in 18 different species. The majority of UCNEs are supposed to be transcriptional regulators of key developmental genes. As most of them occur as clusters near potential target genes, the database is organized along two hierarchical levels: individual UCNEs and ultra-conserved genomic regulatory blocks (UGRBs). UCNEbase introduces a coherent nomenclature for UCNEs reflecting their respective associations with likely target genes. Orthologous and paralogous UCNEs share components of their names and are systematically cross-linked. Detailed synteny maps between the human and other genomes are provided for all UGRBs. UCNEbase is managed by a relational database system and can be accessed by a variety of web-based query pages. As it relies on the UCSC genome browser as visualization platform, a large part of its data content is also available as browser viewable custom track files. UCNEbase is potentially useful to any computational, experimental or evolutionary biologist interested in conserved non-coding DNA elements in vertebrates.
000183546 700__ $$0243606$$aDimitrieva, Slavica$$g190564
000183546 700__ $$0244404$$aBucher, Philipp$$g113607
000183546 773__ $$j41$$qD101-9$$tNucleic Acids Research
000183546 8564_ $$s1659005$$uhttps://infoscience.epfl.ch/record/183546/files/Nucl.%20Acids%20Res.-2013-Dimitrieva-D101-9.pdf$$yPublisher's version$$zPublisher's version
000183546 909C0 $$0252244$$pGR-BUCHER$$xU11780
000183546 909CO $$ooai:infoscience.tind.io:183546$$pSV$$pGLOBAL_SET$$particle
000183546 917Z8 $$x190564
000183546 937__ $$aEPFL-ARTICLE-183546
000183546 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000183546 980__ $$aARTICLE