The histone chaperone SET/TAF-Ibeta interacts functionally with the CREB-binding protein

he oncoprotein SET/TAF-Ibeta is a histone chaperone which is involved in cell-cycle control and chromatin remodeling. Confocal laser scanning microscopy reveals that SET is localized in distinct foci of variable size throughout the nucleoplasm of interphase cells. We report here that SET interacts directly with the acetyltransferase CREB-binding protein (CBP) and enhances the transactivation potential of the transcription coactivator. Our data suggest that the histone chaperone SET regulates the CBP-mediated transcription and may indicate a general principle by which transcriptional regulators cooperate with histone chaperones for gene activation.


Published in:
Biochemical and Biophysical Research Communications, 335, 2, 322–327
Year:
2005
Publisher:
Elsevier
ISSN:
0006-291X
Laboratories:




 Record created 2012-12-13, last modified 2018-03-17


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