A Current-Mode Potentiostat for Multi-Target Detection Tested with Different Lactate Biosensors

Real-time and multi-target detection by wireless implantable devices is of increasing interest for chronic patients. In this work, electrode sharing is proposed to minimize the size of the implantable device when several three-electrode-based sensing sites are needed. An integrated potentiostat and readout circuit for a multi-target biosensor is presented. To realize this, the circuit reads out the sensor current through each working electrode in a current-mode scheme. The maximum detectable current is 8 μA and the simulated input referred current noise of the circuit is 125 pA/pHz at 1 Hz. The circuit was fabricated in 0.18 μm technology and tested for two lactate biosensors fabricated with a commercial lactate oxidase and an engineered one. Chronoamperometry experiments performed with the circuit agree well with a commercial equipment for lactate detection up to 1 mM.

Published in:
Proceedings of the IEEE Biomedical Circuits and Systems Conference (BioCAS 2012)
Presented at:
IEEE Biomedical Circuits and Systems Conference (BioCAS 2012), Hsinchu, Taiwan, November 28-30, 2012

 Record created 2012-12-04, last modified 2019-03-16

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