000182433 001__ 182433
000182433 005__ 20190316235529.0
000182433 0247_ $$2doi$$a10.1242/jcs.01128
000182433 022__ $$a0021-9533
000182433 037__ $$aARTICLE
000182433 245__ $$aThe arithmetic of centrosome biogenesis
000182433 269__ $$a2004
000182433 260__ $$bCompany of Biologists$$c2004
000182433 336__ $$aReviews
000182433 520__ $$aHow do cells regulate centrosome number? A canonical duplication cycle generates two centrosomes from one in most proliferating cells. Centrioles are key to this process, and molecules such as centrins, SAS-4 and ZYG-1 govern daughter centriole formation. Cdk2 activity probably couples centrosome duplication with the S phase, and a licensing mechanism appears to limit centrosome duplication to once per cell cycle. However, such mechanisms must be altered in some cells--for example, spermatocytes--in which centrosome duplication and DNA replication are uncoupled. There are also alternative pathways of centrosome biogenesis. For example, one centrosome is reconstituted from two gametes at fertilization; in this case, the most common strategy involves differential contributions of centrioles and pericentriolar material (PCM) from each gamete. Furthermore, centrioles can sometimes form de novo from no apparent template. This occurs, for instance, in the early mouse embryo and in parthenogenetic species and might rely on a pre-existing seed that resides within PCM but is not visible by ultrastructural analysis.
000182433 700__ $$aDelattre, Marie
000182433 700__ $$g168676$$aGönczy, Pierre$$0243625
000182433 773__ $$j117$$tJournal of cell science$$kPt 9$$q1619-30
000182433 8564_ $$uhttps://infoscience.epfl.ch/record/182433/files/1619.full.pdf$$zPublisher's version$$s336802$$yPublisher's version
000182433 909C0 $$xU11155$$0252248$$pUPGON
000182433 909CO $$qGLOBAL_SET$$pSV$$ooai:infoscience.tind.io:182433$$preview
000182433 917Z8 $$x182396
000182433 937__ $$aEPFL-REVIEW-182433
000182433 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000182433 980__ $$aREVIEW