Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy

We demonstrate label-free imaging of cerebral β-amyloidosis ex vivo and in a living mouse model of Alzheimer's disease using extended focus Fourier domain optical coherence microscopy (xfOCM). xfOCM provides 3D, high-resolution images of individual β-amyloid plaques in the brain parenchyma and vasculature and requires no staining of the Alzheimeric sample under investigation. xfOCM also opens the possibility to perform minimally invasive studies of β-amyloid pathology in vivo, without the use of labeling methods, which potentially confound experimental findings.


Published in:
Journal of Neuroscience, 32, 42, 14548-14556
Year:
2012
Publisher:
Washington, Society for Neuroscience
ISSN:
0270-6474
Laboratories:


Note: The status of this file is: EPFL only


 Record created 2012-11-21, last modified 2018-12-03

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