We present a damage scenario based on multidisciplinary study which covers the key elements of the earthquake risk chain in Visp. Full dynamic rupture simulations are performed using heterogeneous initial distributions, statistically compatible to the database of kinematic inversion results of past earthquakes. The fault is embedded in the 3D velocity model of the area, which is based on an extensive ambient noise measurement campaign. In order to assess the risk in the city of Visp, the buildings were classified based on the screening survey of the building stock. The seismic behavior of each class is described by the mean of fragility curves, partly developed by analytical, numerical and experimental investigations and partly based on existing methods.