000182136 001__ 182136
000182136 005__ 20180913061628.0
000182136 0247_ $$2doi$$a10.1007/s00285-004-0271-9
000182136 022__ $$a0303-6812
000182136 037__ $$aARTICLE
000182136 245__ $$aMultistage carcinogenesis and the fraction at risk
000182136 269__ $$a2004
000182136 260__ $$bSpringer Verlag$$c2004
000182136 336__ $$aJournal Articles
000182136 520__ $$aMultistage carcinogenesis models describe the evolution of the cells in an individual's organ from a normal stage to a pre-neoplastic stage to a neoplastic stage. The triggers for the passage from one stage to the next one are presumed to be genetic alterations, which are not only governed by purely random events but also by individual environmental and genetic factors. We generalize existing models of carcinogenesis to populations composed of heterogeneous individuals, thus taking the environmental and genetic variability into account.
000182136 6531_ $$aCell Transformation, Neoplastic
000182136 6531_ $$aModels, Biological
000182136 700__ $$0241889$$aMorgenthaler, Stephan$$g105911
000182136 700__ $$aHerrero, Pablo
000182136 700__ $$aThilly, William G.
000182136 773__ $$j49$$k5$$q455-67$$tJournal of mathematical biology
000182136 8564_ $$s171453$$uhttps://infoscience.epfl.ch/record/182136/files/art3A10.10072Fs00285-004-0271-9.pdf$$yn/a$$zn/a
000182136 909C0 $$0252209$$pSTAP$$xU10127
000182136 909CO $$ooai:infoscience.tind.io:182136$$pSB$$particle
000182136 917Z8 $$x105911
000182136 937__ $$aEPFL-ARTICLE-182136
000182136 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000182136 980__ $$aARTICLE