Regulatory T-Cells and Associated Pathways in Metastatic Renal Cell Carcinoma (mRCC) Patients Undergoing DC-Vaccination and Cytokine-Therapy
Schwarzer, Adrian; Wolf, Benita; Fisher, Jan L.; Schwaab, Thomas; Olek, Sven; Baron, Udo; Tomlinson, Craig R.; Seigne, John D.; Crosby, Nancy A.; Gui, Jiang; Hampton, Thomas H.; Fadul, Camilo E.; Heaney, John A.; Ernstoff, Marc S.
2012

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Abstract

To evaluate CD4(+)CD25(+)FOXP3(+) T regulatory cells (T(REG)) and associated immune-regulatory pathways in peripheral blood lymphocytes (PBL) of metastatic renal cell carcinoma (mRCC) patients and healthy volunteers. We subsequently investigated the effects of immunotherapy on circulating T(REG) combining an extensive phenotype examination, DNA methylation analysis and global transcriptome analysis.

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Title Regulatory T-Cells and Associated Pathways in Metastatic Renal Cell Carcinoma (mRCC) Patients Undergoing DC-Vaccination and Cytokine-Therapy
Author(s) Schwarzer, Adrian ; Wolf, Benita ; Fisher, Jan L. ; Schwaab, Thomas ; Olek, Sven ; Baron, Udo ; Tomlinson, Craig R. ; Seigne, John D. ; Crosby, Nancy A. ; Gui, Jiang ; Hampton, Thomas H. ; Fadul, Camilo E. ; Heaney, John A. ; Ernstoff, Marc S.
Published in PloS One
Volume 7
Issue 10
Pages e46600
Date 2012
Publisher Public Library of Science
ISSN 1932-6203
DOI https://doi.org/10.1371/journal.pone.0046600
Laboratories ISREC
Record Appears in Scientific production and competences > SV - School of Life Sciences > ISREC - Swiss Institute for Experimental Cancer Research > UNATTRIBUTED-ISREC - ISREC - Unattributed publications
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date 2012-11-05

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