000182082 001__ 182082
000182082 005__ 20190316235516.0
000182082 0247_ $$2doi$$a10.1016/j.cub.2012.06.067
000182082 022__ $$a0960-9822
000182082 02470 $$2ISI$$a000309328500022
000182082 037__ $$aARTICLE
000182082 245__ $$aA Genetic Basis for Altered Sexual Behavior in Mutant Female Mice
000182082 260__ $$bElsevier$$c2012$$aCambridge
000182082 269__ $$a2012
000182082 300__ $$a5
000182082 336__ $$aJournal Articles
000182082 500__ $$aZakany, Jozsef Duboule, Denis England Current biology : CB Curr Biol. 2012 Sep 25;22(18):1676-80. doi: 10.1016/j.cub.2012.06.067. Epub 2012 Aug 2.
000182082 520__ $$aAlthough neural substrates of mammalian female mating behavior have been described [1, 2], the association between complex courtship activity and specific underlying mechanisms remains elusive [3]. We have isolated a mouse line that unexpectedly shows altered female social behavior with increased investigation of males and increased genital biting. We investigated adult individuals by behavioral observation and genetic and molecular neuroanatomy methods. We report exacerbated inverse pursuits and incapacitating bites directed at the genitals of stud males. This extreme deviation from wild-type female courtship segregates with a deletion of the Hoxd1 to Hoxd9 genomic region. This dominant Atypical female courtship allele (HoxD(Afc)) induces ectopic Hoxd10 gene expression in several regions in newborn forebrain transitorily and stably in a sparse subpopulation of cells in the cornu ammonis fields of adult hippocampus, which may thus lead to an abnormal modulation in the sexual behavior of mutant females. The resulting compulsive sexual solicitation behavior displayed by the most affected individuals suggests new avenues to study the genetic and molecular bases of normal and pathological mammalian affect and raises the potential involvement of the hippocampus in the control of female courtship behavior. The potential relevance to human 2q.31.1 microdeletion syndrome [4, 5] is discussed. VIDEO ABSTRACT:
000182082 700__ $$aZakany, Jozsef
000182082 700__ $$g141236$$aDuboule, Denis$$0240276
000182082 773__ $$j22$$tCurrent Biology$$k18$$q1676-1680
000182082 8564_ $$uhttp://www.ncbi.nlm.nih.gov/pubmed/22863319$$zURL
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000182082 937__ $$aEPFL-ARTICLE-182082
000182082 973__ $$rNON-REVIEWED$$sPUBLISHED$$aEPFL
000182082 980__ $$aARTICLE