Chronic angiotensin II receptor blockade induces cardioprotection during ischemia by increased PKC-epsilon expression in the mouse heart
Lange, Stefan A.; Wolf, Benita; Schober, Kristin; Wunderlich, Carsten; Marquetant, Rainer; Weinbrenner, Christof; Strasser, Ruth H.
2007

Abstract

This study was performed to investigate the role of chronic pretreatment with angiotensin II type 1 receptor antagonists (ARB) and angiotensin converting enzyme inhibitors (ACE-I) in myocardial infarction (MI) and ischemic preconditioning (iPC). Little is known about molecular mechanisms of MI and iPC, especially about protein kinase C (PKC) isozyme levels induced by chronic pharmacologic pretreatment with ARB and ACE-I. To address one of the most important signal molecules in iPC, the PKC system was investigated in an ischemia/reperfusion model using isolated mouse hearts.

Details

Title Chronic angiotensin II receptor blockade induces cardioprotection during ischemia by increased PKC-epsilon expression in the mouse heart
Author(s) Lange, Stefan A. ; Wolf, Benita ; Schober, Kristin ; Wunderlich, Carsten ; Marquetant, Rainer ; Weinbrenner, Christof ; Strasser, Ruth H.
Published in Journal of cardiovascular pharmacology
Volume 49
Issue 1
Pages 46-55
Date 2007
ISSN 0160-2446
Keywords
DOI https://doi.org/10.1097/FJC.0b013e31802c2f77
Laboratories ISREC
Record Appears in Scientific production and competences > SV - School of Life Sciences > ISREC - Swiss Institute for Experimental Cancer Research > UNATTRIBUTED-ISREC - ISREC - Unattributed publications
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date 2012-10-29

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