Indoleamine-2,3-dioxygenase enzyme expression and activity in polarized dendritic cells

Polarized mature dendritic cells (DC) can activate cytolytic T-lymphocyte (CTL) responses and may be a more effective clinical strategy in DC-based cancer vaccines. A subset of mature DC can down-regulate the T-cell immune response through expression of indoleamine-2,3-dioxygenase (IDO). We determined whether polarizing DC ex vivo increased IDO expression and activity.


Published in:
Cytotherapy, 11, 8, 1084-9
Year:
2009
ISSN:
1477-2566
Keywords:
Laboratories:




 Record created 2012-10-29, last modified 2018-03-17


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