Organocatalytic Enantioselective One-Pot Four-Component Ugi-Type Multicomponent Reaction for the Synthesis of Epoxy-tetrahydropyrrolo[3,4-

In the presence of a catalytic amount of chiral BINOL-derived phosphoric acid (TRIP), reaction of an α-isocyanoacetate 1, an aldehyde 2, an aniline 3 followed by addition of a toluene solution of α,β-unsaturated acyl chloride 5 afforded oxa-bridged tricycle 6 in excellent yield, diastereoselectivity and enantioselectivity. Six chemical bonds, five stereogenic centers, three cycles were formed in this one pot four-component reaction.


Published in:
Chemistry - A European Journal, 18, 40, 12624-12627
Year:
2012
Publisher:
Weinheim, Wiley-Blackwell
ISSN:
0947-6539
Keywords:
Laboratories:




 Record created 2012-10-01, last modified 2018-03-17


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