Nanosystems - based on the systematic application of nano-technologies - will create a large market of applications and a renewed perspective for electronic design and manufacturing companies. Such systems will be the fundamental building blocks of wearable and ambient systems, to gather and integrate heterogeneous data in real time and to operate and communicate in a wireless and ultra low power mode. The design of these systems will be enabled by the hybridization of manufacturing technologies to attain unprecedented levels performance as well as to diversify applications by means of integrated circuits and sensors. To accomplish this ambitious goal, new technologies and architectures must be matched and tailored to the operational environment by solving novel challenging design and optimization problems, through the creation of novel design methodologies and tools.