Ultrasensititve system for the real time detection of H2O2 based on strong coupling in a bio-plasmonic system
We theoretically investigate the dependence of the different parameters of an optical biosensor for the detection of Hydrogen peroxide (H2O2) based on absorption enhancement of Cytochrome c molecules near gold nanoparticles. H2O2 is a major reactive oxygen species which is involved in signaling pathways and oxidative stress in cells. We use the Green's function approach as well as confirm the corresponding simulation results using the surface integral formulation. Further we show that this technique can be applied for detection of other small molecules, like oxygen and carbon monoxide.
Keywords: Plasmon resonance ; energy transfer ; absorption ; cytochrome c ; gold nanoparticle ; Pret ; hemoglobin ; hydrogen peroxide ; Resonance Energy-Transfer ; Free-Radicals ; Human-Disease ; Metal-Ions ; Glutathione ; Nanospectroscopy ; Sensor
Record created on 2012-07-27, modified on 2016-08-09