000180313 001__ 180313
000180313 005__ 20181203022816.0
000180313 0247_ $$2doi$$a10.1021/ic202739d
000180313 02470 $$2ISI$$a000305853600019
000180313 037__ $$aARTICLE
000180313 245__ $$aEnhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages
000180313 269__ $$a2012
000180313 260__ $$c2012
000180313 336__ $$aJournal Articles
000180313 520__ $$aThree generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyrG) or alcohol (pyr(Gn center dot OH)) (n = 1-3), were synthesized, and the pyrenyl group of the dendritic molecules was encapsulated in the arene ruthenium metallacages, [Ru-6(p-cymene)(6)(OO boolean AND OO)(3)(tpt)(2)](6+) (OO boolean AND OO = 5,8-dioxydo-1,4-naphtaquinonato (donq) [1](6+) and 6,11-dioxydo-5,12-naphtacenedionato (dotq) [2](6+); tpt = 2,4,6-tri(pyridin-4-yl)-1,3,5-triazine). The host guest properties of [guest subset of 1](6+) and [guest subset of 2](6+) were studied in solution by NMR and UV-vis spectroscopic methods, thus allowing the determination of the affinity constants. Moreover, the cytotoxicity of these water-soluble host guest systems and the pyrenyl-dendrimers was evaluated on human ovarian cancer cells.
000180313 6531_ $$a2,2-Bis(Hydroxymethyl)Propionic Acid
000180313 6531_ $$aDendritic Macromolecules
000180313 6531_ $$aMolecular Architecture
000180313 6531_ $$aDesigning Dendrimers
000180313 6531_ $$aOrganometallic Cages
000180313 6531_ $$aConvergent Approach
000180313 6531_ $$aDelivery
000180313 6531_ $$aDendrons
000180313 6531_ $$aPolymers
000180313 6531_ $$aCarriers
000180313 700__ $$aPitto-Barry, Anais
000180313 700__ $$0242074$$g187546$$aZava, Olivier
000180313 700__ $$0240015$$g149418$$aDyson, Paul J.
000180313 700__ $$aDeschenaux, Robert
000180313 700__ $$aTherrien, Bruno
000180313 773__ $$j51$$tInorganic Chemistry$$q7119-7124
000180313 909C0 $$xU9$$0252010$$pLCOM
000180313 909CO $$pSB$$particle$$ooai:infoscience.tind.io:180313
000180313 917Z8 $$x135992
000180313 937__ $$aEPFL-ARTICLE-180313
000180313 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000180313 980__ $$aARTICLE