Towards a molecular architecture of centriole assembly
The centriole is an evolutionarily conserved macromolecular structure that is crucial for the formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first characterized decades ago with the advent of electron microscopy, revealing a striking ninefold radial arrangement of microtubules. However, it is only recently that the molecular mechanisms governing centriole assembly have begun to emerge, including the elucidation of the crucial role of spindle assembly abnormal 6 (SAS-6) proteins in imparting the ninefold symmetry. These advances have brought the field to an exciting era in which architecture meets function.
Keywords: C. Elegans Embryos ; Centrosome Duplication ; Basal Body ; Human-Cells ; Caenorhabditis-Elegans ; 9-Fold Symmetry ; Procentriole Formation ; Regulates Centriole ; Daughter Centriole ; Epithelial-Cells
Record created on 2012-07-20, modified on 2016-08-09